With special care, the drug should be prescribed to patients with gastrointestinal diseases (ulcerative colitis, Crohn's disease) in the anamnesis, arterial hypertension, chronic heart failure, infectious diseases, as well as elderly patients.
With caution and only under the supervision of a doctor, the drug is prescribed for patients with bronchial asthma, allergic rhinitis, nasal polyposis, chronic obstructive airways diseases.
During the period of taking the drug, alcohol intake should be avoided..
Mode of application
Inside, a dose of 10 to 30 mg is prescribed once a day. Buy Piroxicam 20mg for Arthritis in US from PerfectHealthUs Rectally (in the rectum) is prescribed in a dose of 10-40 mg 1-2 times a day. In the treatment of acute gout, the initial dose of the drug is 40 mg in a single dose in the first 2 days, then for 4-6 days at a dose of 40 mg once a day or 20 mg 2 times a day. Intramuscular administration at a dose of 20-40 mg once a day is used to treat acute conditions or to relieve (relieve) an exacerbation of the chronic process. After stopping the acute stage of the process, they switch to maintenance therapy with tablets or capsules. The gel or cream should be applied in a small amount (column of 5-10 mm) to the affected areas 3-4 times a day. An occlusive dressing is not applied. Do not apply the drug on damaged skin. Avoid contact with the eyes or mucous membranes. In the process of treatment, it is necessary to monitor the functional state of the liver and the picture of peripheral blood.
Piroxicam inhibits the activity of the enzyme cyclooxygenase 1 and 2, reduces the production of thromboxanes and prostaglandins (including PGE1, PGE2 alpha, PGE2). http://www.medicinenet.com/piroxicam/article.htm Piroxicam inhibits platelet aggregation and phagocytosis. When ingested, piroxicam is well absorbed from the gastrointestinal tract, the maximum concentration is reached after 3-5 hours. Within 7-12 days, the equilibrium concentration of piroxicam in the blood is established. With plasma proteins, the drug binds to 97–99%. In the liver, piroxicam undergoes metabolism (conjugates and oxidizes) to form the main metabolites of N-methyl-benzosulfonamide, 5-hydroxypyroxicam and others, which are pharmacologically inactive.
The half-life of piroxicam is approximately 50 hours, with liver diseases it can increase. It is excreted by piroxicam by the kidneys and intestines (in the urine the amount of the drug is 2 times greater than in feces), mainly in the form of glucuronides (5% is excreted unchanged). Piroxicam is excreted in breast milk and passes through the placenta. In the body does not cumulate.
Pyroxicam weakens pain, inflammation symptoms with any method of use. With joint syndrome, pain and inflammation in the joints stops or weakens when moving and at rest, reduces swelling and morning stiffness of the joints. In studies of chronic and subacute toxicity in animals, it was shown that the most frequent manifestation of toxicity with prolonged use of piroxicam is damage to the gastrointestinal tract and renal papillary necrosis. No teratogenic effects and effects on fertility in animals were found. Piroxicam increases the possibility of delaying the birth act and pathological birth in animals. The toxic effect of piroxicam on the gastrointestinal tract is especially pronounced in women in the third trimester of pregnancy.